The study of bone density is part of a larger body of research being conducted by Nokoff and her co-investigators on the long-term health effects of gender-affirming therapy in children and adolescents. So far, the “bone mineral density effects of these therapies are understudied,” warned Natalie Nokoff, MD, who presented a cross-sectional study at ENDO 2022: The Endocrine Society Annual Meeting, which was held in Atlanta last month. The problem worsens as the time during which these patients receive sex steroid hormones increases. ATLANTA ― Among transgender youth who receive puberty-delaying or gender-affirming hormone therapy, bone mineral density (BMD) is lower relative to age-based norms, and this is true regardless of gender assignment at birth.
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